Translational Physiology Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure
نویسندگان
چکیده
Beverly A. Rothermel, Kambeez Berenji, Paul Tannous, William Kutschke, Asim Dey, Bridgid Nolan, Ki-Dong Yoo, Elaine Demetroulis, Michael Gimbel, Barry Cabuay, Mohsen Karimi, and Joseph A. Hill Donald W. Reynolds Cardiovascular Clinical Research Center and Division of Cardiology, Department of Internal Medicine, and Department of Molecular Biology, University of Texas Southwestern Medical Center, Dallas, Texas; and Departments of Internal Medicine and Surgery, University of Iowa Carver College of Medicine, Iowa City, Iowa
منابع مشابه
Differential activation of stress-response signaling in load-induced cardiac hypertrophy and failure.
Hypertrophic growth of the myocardium occurs in most forms of heart failure and may contribute to the pathogenesis of the failure state. Little is known about the regulatory mechanisms governing the often-coexisting phenotypes of hypertrophy, systolic failure, and diastolic stiffness that characterize clinical disease. We hypothesized that intracellular signaling pathways are differentially act...
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